In this Life Science Leader article, Agios CEO Jackie Fouse shares her personal perspective on Agios’ strategic transformation to focus solely on genetically defined diseases by divesting the company’s oncology business. She also shares advice and learnings for other company leaders considering a major shift. “Any time a company undergoes organizational change — even if it’s a good change — the road there is not necessarily an easy one,” she writes. “I’d like to share a few things that might make it — or any major decision — easier for you.”