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Melissa McLaughlin
SVP Human Resources

Our Research in Glioma

Read the inside story behind our discovery of the first brain-penetrant pan-IDHm inhibitor to enter pivotal trials.

Our Research Focus

Cancer Metabolism

Inhibit key enzymes in cancer cell specific metabolic pathways to disrupt tumor cell proliferation and survival

Rare Genetic Diseases

Restore defective metabolic pathways in disease cells that cause rare genetic disorders of metabolism

Metabolic
Immuno-Oncology

Alter the metabolic state of immune cells to enhance the body’s anti-tumor response

Boldly Pursuing Excellence and Innovation

We are a research-driven organization focused on creating transformative medicines by combining expertise in metabolism and precision medicine.

research platform

The Spirit of Agios

The Spirit of Agios

At Agios, our culture and values are embodied in the Greek word Arete, the ancient ideal of excellence and fulfillment of one’s potential to which our employees aspire. Together, we are driven by a boundless passion for our work, and we pride ourselves on fostering an interconnected environment that encourages creative scientific collaboration across disciplines.

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Passion for Discovery

our pipeline

Agios has leveraged its core capabilities in cellular metabolism and precision medicine to build a product engine that is focused in the therapeutic areas of cancer and rare genetic diseases.


CANDIDATE

Drug Discovery
Early Stage Clinical Development
Late Stage Clinical Development
Regulatory Submission

APPROVED
R/R AML
 
Phase 1 Dose-Escalation and Expansion
 
EU
U.S.
Frontline AML Monotherapy
Phase 1 Dose-Escalation and Expansion
U.S.
IC-Eligible Frontline AML
 
Phase 1b 7+3 Combo
Phase 3 HOVON 7+3 Combo
IC-Ineligible Frontline AML
 
Phase 1/2 Azacitidine Combo
Phase 3 AGILE Azacitidine Combo
Cholangio
 
 Phase 1 Dose-Escalation and Expansion
Phase 3 ClarlDHy
R/R MDS
Phase 1 Expansion
R/R AML
 
Phase 3 IDHENTIFY
U.S.
IC-Eligible Frontline AML
 
Phase 1b 7+3 Combo
Phase 3 HOVON 7+3 Combo
IC-Ineligible Frontline AML
 
Phase 1/2 Azacitidine Combo
  • Celgene has worldwide development and commercialization rights.Agios has U.S. co–promotion and royalty rights.
PK Deficiency – Not Regularly Transfused
 
Phase 2 DRIVE PK
Phase 3 ACTIVATE
PK Deficiency – Regularly Transfused
Phase 3 ACTIVATE-T
Thalassemia
Phase 2 Study
Low-Grade Glioma
 
Perioperative Study
Phase 3 INDIGO
MTAP-Deleted NSCLC and Pancreatic Cancer
 
Phase 1 Dose-Escalation and Expansion

IC = Intensive Chemotherapy

The safety and efficacy of the agents and uses under investigation have not been established. There is no guarantee that the agents will receive health authority approval or become commercially available in any country for the uses being investigated.

Recent News & Events

05/19/2020

Agios Announces Publication of TIBSOVO® Phase 3 Data in The Lancet Oncology Demonstrating Significant Improvement in Progression-Free Survival Compared to Placebo in Previously Treated IDH1-Mutant Cholangiocarcinoma Patients
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05/14/2020

Agios to Present Updated Clinical Proof-of-Concept Data from the Phase 2 Study of Mitapivat in Thalassemia in Oral Presentation at the European Hematology Association Annual Congress
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05/13/2020

Agios to Present Updated Data from the Phase 1 Study of Vorasidenib in Non-enhancing Glioma in Oral Presentation at the American Society of Clinical Oncology Annual Meeting
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05/12/2020

Agios to Present at the RBC Capital Markets Global Healthcare Virtual Conference on Tuesday, May 19, 2020
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Agios has a dynamic culture that supports our employees’ unwavering commitment to science and patients.

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