Tak Mak, Ph.D.

Dr. Mak is a preeminent researcher of the biology of the immune system, the biology of apoptosis and the pathogenesis of cancer. His key contributions include:

  • Discovering the T-Cell receptor
  • Characterizing the tumorigenic functions of the tumor suppressor protein p53 and the kinase Chk2
  • Identifying CPT1C as a tumor-specific gene product that plays an important role in the utilization of fatty acids as an alternative energy source of cancer cells
  • Discovery of the function of CTLA-4