Lewis C. Cantley, Ph.D.
Dr. Cantley is a foremost expert in understanding the biochemical pathways linking cancer and energy metabolism. His key contributions include:
- Discovering the phosphatidylinositol-3-kinase (PI3K) signaling pathway
- Characterizing the mechanism by which PI3K is activated by growth factors and oncogenes and elucidating pathways downstream of PI3K, including the AKT/PKB signaling pathway
- Pioneering the application of fluorescence resonance energy transfer (FRET) for studying small molecule cell membrane transport
- Discovering pyruvate kinase M2 (PKM2) as a “hub” to integrate growth factor signaling and aerobic glycolysis, an evolution in the understanding of the Warburg effect