ORAL PRESENTATION

Abstract #625: Ivosidenib Improves Overall Survival Relative to Standard Therapies in Relapsed or Refractory Mutant IDH1 AML: Results from Matched Comparisons to Historical Controls
Date & Time: Monday, December 7, 2020 at 10:15 a.m. PST
Oral Session: 903. Health Services Research – Malignant Conditions (Myeloid Disease): Treatment and Publication Patterns in Myeloid Malignancies
Presenter: Peter Paschka, Klinikum Ludwigshafen
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POSTER PRESENTATIONS – RARE GENETIC DISEASES

Abstract #1627: Mortality Among Veterans with a Diagnosis of Pyruvate Kinase (PK) Deficiency: A Real-World Study Using US Veterans Health Administration Data
Poster Session Date & Time: Saturday, December 5, 2020 from 7:00 a.m. – 3:30 p.m. PST
Poster Session: 904. Outcomes Research – Non-Malignant Conditions: Poster I
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Abstract #1679: Early-Onset Osteopenia and Osteoporosis in Patients with Pyruvate Kinase Deficiency
Poster Session Date & Time: Sunday, December 6, 2020 from 7:00 a.m. – 3:30 p.m. PST
Poster Session: 101. Red Cells and Erythropoiesis, Structure and Function, Metabolism, and Survival, Excluding Iron: Poster II
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Abstract #2583: Baseline Characteristics of Patients in Peak: A Global, Longitudinal Registry of Patients with Pyruvate Kinase Deficiency
Poster Session Date & Time: Monday, December 7, 2020 from 7:00 a.m. – 3:30 p.m. PST
Poster Session: 101. Red Cells and Erythropoiesis, Structure and Function, Metabolism, and Survival, Excluding Iron: Poster III
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Abstract #2600: Proof of Concept for the Oral Pyruvate Kinase Activator Mitapivat in Adults with Non-Transfusion-Dependent Thalassemia: Interim Results from and Ongoing, Phase 2, Open-Label, Multicenter Study
Poster Session Date & Time: Monday, December 7, 2020 from 7:00 a.m. – 3:30 p.m. PST
Poster Session: 112. Thalassemia and Globin Gene Regulation: Poster III
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POSTER PRESENTATIONS – ONCOLOGY

Abstract #1943: Molecular Characterization of Clinical Response and Relapse in Patients with IDH1-Mutant Newly Diagnosed Acute Myeloid Leukemia Treated with Ivosidenib and Azacitidine
Poster Session Date & Time: Sunday, December 6, 2020 from 7:00 a.m. – 3:30 p.m. PST
Poster Session: 615. Acute Myeloid Leukemia: Commercially Available Therapy, excluding Transplantation: Poster II
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Abstract #2814: AGILE: Phase 3, Double-Blind, Randomized, Placebo-Controlled Study of Ivosidenib in Combination with Azacitidine in Adults with Newly Diagnosed Acute Myeloid Leukemia and an IDH Mutation
Poster Session Date & Time: Monday, December 7, 2020 from 7:00 a.m. – 3:30 p.m. PST
Poster Session: 613. Acute Myeloid Leukemia: Clinical Studies: Poster III
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Abstract #2900: Longitudinal Molecular Profiling in Patients with IDH1-Mutant Newly Diagnosed Acute Myeloid Leukemia Treated with Ivosidenib
Poster Session Date & Time: Monday, December 7, 2020 from 7:00 a.m. – 3:30 p.m. PST
Poster Session: 617. Acute Myeloid Leukemia: Biology, Cytogenetics, and Molecular Markers in Diagnosis Prognosis: Poster III
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PRESENTATIONS BY EXTERNAL COLLABORATORS

Oral Presentations

Abstract #84: The Pyruvate Kinase Activator AG-348 ameliorates anemia and prevents iron overload in a mouse model of hereditary spherocytosis
Date & Time: Saturday, December 5, 2020 at 10:15 a.m. PST
Oral Session: 101. Red Cells and Erythropoiesis, Structure, and Functions, Metabolism, and Survival, Excluding Iron: Mechanisms, Diagnosis and Treatment of Inherited
Presenter: Alessandro Mattè, BSc, PhD University of Verona and AOUI Verona
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Abstract #681: Phase 1 Multiple Ascending Dose Study of Safety, Tolerability, and Pharmacokinetics/Pharmacodynamics of Mitapivat (AG-348) in Subjects with Sickle Cell Disease
Date & Time: Monday, December 7, 2020 at 2:30 p.m. PST
Oral Session: 114. Hemoglobinopathies Excluding Thalassemia – Clinical: Novel Treatments for Sickle Cell Disease
Presenter: Julia Z. Xu, Sickle Cell Branch, National Heart, Lung, and Blood Institute
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Poster Presentation

Abstract #2402: A Phase I Study of the IDH2 inhibitor enasidenib as maintenance therapy for IDH2-mutant myeloid neoplasms following hematopoietic
Date & Time: Sunday, December 6, 2020 from 7:00 a.m. – 3:30 p.m. PST
Poster Session: 723. Clinical Allogeneic and Autologous Transplantation: Late Complications and Approaches to Disease Recurrence: Post II
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