Click here for review articles on cancer metabolism by Agios founders and collaborators.
Publications by Agios scientists:
American Association for Cancer Research (AACR) Annual Meeting 2012; April 2012
X-Ray structure of human glutaminase in complex with BPTES and analysis of BPTES-resistant mutants
American Association for Cancer Research (AACR) Annual Meeting 2012; April 2012
IDH mutations and tumorigenicity
American Association for Cancer Research (AACR) Annual Meeting 2012; April 2012
Induced dependency on amino acid metabolism in proliferating cancer cells upon PKM2 activation
Nature; February 2012
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.
The Oncologist ; January 2012
Cancer-associated isocitrate dehydrogenase mutations.
Biochemistry; December 2011
Full-length human glutaminase in complex with an allosteric inhibitor.
The Oncologist; December 2011
Frequent Mutation of Isocitrate Dehydrogenase (IDH)1 and IDH2 in Cholangiocarcinoma Identified Through Broad-Based Tumor Genotyping.
Nature Genetics; November 2011
Ollier disease and Maffucci syndrome are caused by somatic mosaic mutations of IDH1 and IDH2.
Nature; August 2011
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer.
Nature Reviews Cancer; February 2011
Regulation of cancer cell metabolism
Cancer Cell; December 2010
Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation.
Oncogene; December 2010
Cancer-associated IDH mutations: biomarker and therapeutic opportunities.
Trends in Molecule Medicine; September 2010
IDH mutations in glioma and acute myeloid leukemia.
Cancer Cell; March 2010
The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting a-Ketoglutarate to 2-Hydroxyglutarate
Journal of Experimental Medicine; February 2010
Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations
Nature; November 2009
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate(2HG)